Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.60 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.60 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.60 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.60 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 17/20 | 0.96 |
| ▸ | HTR2A | P28223 | 14/20 | 0.96 |
| ▸ | HTR2B | P41595 | 13/20 | 0.96 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164205 | 0.98 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Hydrochloric Acid SCHEMBL174589 | 0.96 | HTR2C (0.96) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Iodide SCHEMBL174548 | 0.96 | HTR2C (0.96) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Water SCHEMBL16465743 | 0.96 | HTR2C (0.96) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Hydrochloric Acid SCHEMBL175004 | 0.95 | HTR2C (0.93) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Hydrochloric Acid SCHEMBL175003 | 0.95 | HTR2C (0.93) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Sulfuric Acid SCHEMBL174315 | 0.89 | HTR2C (0.81) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Phosphoric Acid SCHEMBL174885 | 0.89 | HTR2C (0.81) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Fumaric Acid SCHEMBL175130 | 0.85 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Glycolic Acid SCHEMBL173573 | 0.85 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |