Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801448 | 0.83 | HRH4 (0.53) | PIK3CAPIK3R1KDM4EPDE4APDE4B | |
| SCHEMBL1284016 | 0.83 | GBA1 (0.52) | KITALDH1A1POLBMAPTHTT | |
| SCHEMBL31241514 | 0.82 | PIK3R1 (0.46) | PIK3CAPIK3R1KDM4EPOLBHPGD | |
| SCHEMBL20589783 | 0.82 | PDE4A (0.57) | PIK3CAPIK3R1KDM4EPDE4APDE4B | |
| SCHEMBL31259505 | 0.78 | HTR2C (0.61) | PIK3CAPIK3R1KDM4EPDE4APDE4B | |
| SCHEMBL31259506 | 0.78 | HTR2C (0.61) | PIK3CAPIK3R1KDM4EPDE4APDE4B | |
| SCHEMBL189594 | 0.78 | PIK3CA (0.72) | PIK3CAPIK3R1KDM4EPDE4APDE4B | |
| SCHEMBL14674470 | 0.77 | PRKCI (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31241515 | 0.76 | KDM4E (0.46) | PIK3CAKDM4EPDE4APDE4BPDE4C | |
| SCHEMBL19995316 | 0.75 | ABL1 (0.43) | MAPTHTR1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385832-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | Curis, Inc. (US) | 2011-11-16 | — | — | EP | disclosed |
| US-8040979-B2 | Generating a phase value for a complex signal | INFINEON TECHNOLOGIES AG (DE) | 2011-10-18 | — | — | US | disclosed |
| WO-2010080996-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. (US) | 2010-07-15 | — | — | WO | disclosed |