SCHEMBL17459529

SCHEMBL17459529

COC(=O)c1c(C)cc(-c2ccccc2)cc1-c1ccc(OC)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.50
GABRG2 P18507 1/20 0.50
GABRB3 P28472 1/20 0.50
GABRA5 P31644 1/20 0.50
GABRA3 P34903 1/20 0.50
GABRA2 P47869 1/20 0.50
KDM4E B2RXH2 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
BACE1 P56817 3/20 0.48
HTT P42858 1/20 0.48
EGFR P00533 1/20 0.47
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
KMT2A Q03164 1/20 0.46
GFER P55789 1/20 0.46
ATM Q13315 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17459525 0.92 HTT (0.55) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL17459505 0.89 GFER (0.54) KDM4EBACE1HTTMEN1ALDH1A1
SCHEMBL17459507 0.89 HTT (0.50) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL17459519 0.86 SLC6A4 (0.54) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL6053412 0.79 HTT (0.54) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL29045583 0.77 MEN1 (0.53) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL17459516 0.76 PTPN1 (0.51) KDM4ECYP1A2CYP2C19EGFRMEN1
SCHEMBL17459524 0.76 HPGD (0.45) KDM4ECYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL14149752 0.75 BACE1 (0.56) KDM4EBACE1HTTMEN1ALDH1A1
SCHEMBL17459528 0.75 PTGS1 (0.49) KDM4EBACE1ALDH1A1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016013976-A1 METHOD OF FORMING A MULTI-SUBSTITUTED BENZENE COMPOUND NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-01-28 WO claimed
WO-2016013976-A1 METHOD OF FORMING A MULTI-SUBSTITUTED BENZENE COMPOUND NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-01-28 WO disclosed
WO-2016013976-A1 METHOD OF FORMING A MULTI-SUBSTITUTED BENZENE COMPOUND NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-01-28 WO disclosed