Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 15/20 | 0.60 |
| ▸ | KCNQ2 | O43526 | 15/20 | 0.60 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17468576 | 0.89 | KCNQ3 (0.54) | KCNQ3KCNQ2KMONPC1RAB9A | |
| SCHEMBL17460368 | 0.86 | KCNQ3 (0.62) | KCNQ3KCNQ2RAB9APDE4BPDE4D | |
| SCHEMBL17468704 | 0.85 | KCNQ3 (0.58) | KCNQ3KCNQ2PDE4BPDE4D | |
| SCHEMBL17460381 | 0.84 | KCNQ3 (0.47) | KCNQ3KCNQ2KMONPC1RAB9A | |
| SCHEMBL17460387 | 0.79 | JAK2 (0.45) | KCNQ3KCNQ2 | |
| SCHEMBL3698052 | 0.78 | KCNQ3 (0.61) | KCNQ3KCNQ2 | |
| SCHEMBL17460397 | 0.78 | KCNQ3 (0.48) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17468719 | 0.78 | PDE4B (0.52) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17460369 | 0.77 | PDE4B (0.59) | KCNQ3KCNQ2PDE4BPDE4D | |
| SCHEMBL17468695 | 0.77 | PDE4B (0.56) | KCNQ3KCNQ2PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172210-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS | Pfizer Inc (US) | 2017-05-31 | — | — | EP | disclosed |
| WO-2016012896-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2016-01-28 | — | — | WO | disclosed |