Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747434 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1KMT2AMEN1PARP10 | |
| SCHEMBL1746224 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1KMT2AMEN1PARP10 | |
| SCHEMBL1746006 | 0.87 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1219147 | 0.87 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1219145 | 0.87 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1221299 | 0.85 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1221301 | 0.85 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1745983 | 0.85 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1745984 | 0.85 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KMT2AMEN1ALDH1A1 | |
| SCHEMBL1747123 | 0.81 | CA1 (0.40) | HSP90AA1HSP90AB1KMT2APARP10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380879-B1 | Tetrahydroindolone and tetrahydroindazolone derivatives | ESANEX INC (US) | 2017-07-12 | — | — | EP | disclosed |
| EP-1856057-B1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX INC (US) | 2014-10-15 | — | — | EP | disclosed |
| EP-2380879-A1 | Tetrahydroindolone and tetrahydroindazolone derivatives | Serenex, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20110252835-A1 | HEAT PUMP (SERVER) COUPLED WASHER AND DRYER PAIR | WHIRLPOOL CORPORATION (US) | 2011-10-20 | — | — | US | disclosed |