⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31711888 | 0.74 | — | — | |
| SCHEMBL7265168 | 0.70 | FFAR3 (0.38) | — | |
| SCHEMBL1744112 | 0.70 | — | — | |
| SCHEMBL1746023 | 0.70 | — | — | |
| SCHEMBL8611928 | 0.69 | TSHR (0.35) | — | |
| SCHEMBL153693 | 0.65 | — | — | |
| SCHEMBL7261794 | 0.65 | — | — | |
| SCHEMBL7720783 | 0.65 | — | — | |
| SCHEMBL4706256 | 0.65 | CYP2C19 (0.31) | — | |
| SCHEMBL2923075 | 0.65 | CYP2C19 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592467-B2 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. (US) | 2013-11-26 | — | — | US | disclosed |
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-1926729-B1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LAB (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-2386556-A1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110254413-A1 | CASING OF ELECTRONIC DEVICE AND MANUFACTURING METHOD THEREOF | ASUSTEK COMPUTER INC. (TW) | 2011-10-20 | — | — | US | disclosed |
| US-20090326222-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-12-31 | — | — | US | disclosed |
| US-7576110-B2 | Benzothiazole cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1926729-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LABORATORIES (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007038074-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LABORATORIES (US) | 2007-04-05 | — | — | WO | disclosed |
| US-20070066588-A1 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. | 2007-03-22 | — | — | US | disclosed |