Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.59 |
| ▸ | PDE2A | O00408 | 1/20 | 0.59 |
| ▸ | PDE5A | O76074 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.30 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17464699 | 1.00 | PDE10A (0.59) | PDE10APDE2APDE5AABCB1PDE4A | |
| SCHEMBL17464694 | 1.00 | PDE10A (0.59) | PDE10APDE2APDE5AABCB1PDE4A | |
| SCHEMBL17471103 | 0.82 | PDE10A (0.64) | PDE10APDE2APDE5ASMN1; SMN2MAPT | |
| SCHEMBL17464704 | 0.81 | PDE10A (0.86) | PDE10APDE2APDE5AALOX5PTGS1 | |
| SCHEMBL17471106 | 0.81 | PDE10A (0.86) | PDE10APDE2APDE5AALOX5PTGS1 | |
| SCHEMBL17464697 | 0.81 | PDE10A (0.86) | PDE10APDE2APDE5AALOX5PTGS1 | |
| SCHEMBL18905618 | 0.79 | PDE10A (0.55) | PDE10APDE2APDE5AHTTSMN1; SMN2 | |
| SCHEMBL18412709 | 0.79 | PDE10A (0.71) | PDE10APDE2APDE5AALOX5PTGS1 | |
| SCHEMBL18859031 | 0.77 | PDE10A (0.55) | PDE10APDE2APDE5AABCB1ALOX5 | |
| SCHEMBL18412693 | 0.76 | PDE10A (0.81) | PDE10APDE2APDE5AALOX5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850238-B2 | Optically active PDE10 inhibitor | OMEROS CORPORATION (US) | 2017-12-26 | — | — | US | disclosed |
| US-20170096420-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | OMEROS CORPORATION | 2017-04-06 | — | — | US | disclosed |
| US-9493447-B2 | Optically active PDE10 inhibitor | OMEROS CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160024070-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | OMEROS CORPORATION | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170096420-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | PDE3A, PDE10A, PDE3B | PDE10A 2/4885PDE2A 5/4885PDE5A 4/4885 |
| US-20160024070-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | PDE3A, PDE10A, PDE3B | PDE10A 2/4885PDE2A 5/4885PDE5A 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.