⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1481502 | 0.75 | — | — | |
| SCHEMBL12720181 | 0.67 | — | — | |
| SCHEMBL10259402 | 0.65 | — | — | |
| SCHEMBL17663370 | 0.59 | — | — | |
| SCHEMBL15811601 | 0.57 | — | — | |
| SCHEMBL10213479 | 0.57 | — | — | |
| SCHEMBL14473605 | 0.57 | — | — | |
| SCHEMBL7703054 | 0.50 | — | — | |
| SCHEMBL15001014 | 0.48 | — | — | |
| SCHEMBL8537 | 0.47 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180057484-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | OMEROS CORP (US) | 2018-03-01 | — | — | US | disclosed |
| US-9850238-B2 | Optically active PDE10 inhibitor | OMEROS CORPORATION (US) | 2017-12-26 | — | — | US | disclosed |
| US-9650368-B2 | Processes and intermediates for the preparation of a PDE10 inhibitor | OMEROS CORPORATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-20170096420-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | OMEROS CORPORATION | 2017-04-06 | — | — | US | disclosed |
| US-9493447-B2 | Optically active PDE10 inhibitor | OMEROS CORPORATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160024070-A1 | OPTICALLY ACTIVE PDE10 INHIBITOR | OMEROS CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-20160024069-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF A PDE10 INHIBITOR | OMEROS CORPORATION | 2016-01-28 | — | — | US | disclosed |