SCHEMBL1746607

SCHEMBL1746607

C#CCCNCCO.Cc1cc(OCC=C(c2ccc(Cl)cc2)c2ccc(C#CCN(C)CCO)cc2)ccc1OCC(=O)O

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 17/20 0.43
PTGDR2 Q9Y5Y4 2/20 0.37
PPARG P37231 2/20 0.36
PPARA Q07869 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1819063 0.91 PPARD (0.50) PPARDPTGDR2PPARGPPARA
SCHEMBL1744374 0.91 PPARD (0.50) PPARDPTGDR2PPARGPPARA
SCHEMBL1744375 0.91 PPARD (0.50) PPARDPTGDR2PPARGPPARA
SCHEMBL1746400 0.83 PPARD (0.52) PPARDPPARGPPARA
SCHEMBL1746398 0.83 PPARD (0.52) PPARDPPARGPPARA
SCHEMBL1746390 0.82 PPARD (0.55) PPARDPTGDR2PPARGPPARA
SCHEMBL1746389 0.82 PPARD (0.55) PPARDPTGDR2PPARGPPARA
SCHEMBL1746384 0.82 PPARD (0.55) PPARDPTGDR2PPARGPPARA
SCHEMBL1744912 0.78 PPARD (0.52) PPARDPPARGPPARA
SCHEMBL1744908 0.78 PPARD (0.52) PPARDPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2386540-A1 Novel compounds, their preparation and use High Point Pharmaceuticals, LLC (US) 2011-11-16 EP disclosed
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS HIGH POINT PHARMACEUTICALS, LLC (US) 2011-10-06 US disclosed
US-7943613-B2 Compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2011-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS PPARG, PPARA, PPARD PPARD 3/4885PTGDR2 83/4885PPARG 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.