Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.37 |
| ▸ | JAK1 | P23458 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | LTK | P29376 | 2/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.32 |
| ▸ | CLK2 | P49760 | 2/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17467700 | 1.00 | TYRO3 (0.39) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1498952 | 0.92 | TYRO3 (0.37) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL2084499 | 0.92 | TYRO3 (0.37) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1499019 | 0.90 | AXL (0.46) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1499135 | 0.88 | TYRO3 (0.36) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1498953 | 0.86 | TYRO3 (0.35) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL2084501 | 0.86 | TYRO3 (0.35) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL1498950 | 0.86 | JAK2 (0.37) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL12832464 | 0.85 | JAK2 (0.38) | TYRO3AXLMERTKJAK2JAK1 | |
| SCHEMBL12832623 | 0.85 | JAK2 (0.38) | TYRO3AXLMERTKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249145-B2 | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2016-02-02 | — | — | US | disclosed |