SCHEMBL1747183

SCHEMBL1747183

Cc1cc(OCC=C(c2ccc(F)cc2)c2ccc(C#CCN3CCOCC3)cc2)ccc1OC(C)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 8/20 0.46
MAPK14 Q16539 2/20 0.41
PPARG P37231 4/20 0.41
PPARA Q07869 4/20 0.41
MMP13 P45452 2/20 0.36
MMP2 P08253 1/20 0.36
MMP3 P08254 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
FKBP1A P62942 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
PIK3CA P42336 1/20 0.34
PIK3CG P48736 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1747176 1.00 PPARD (0.46) PPARDMAPK14PPARGPPARAMMP13
SCHEMBL1747180 1.00 PPARD (0.46) PPARDMAPK14PPARGPPARAMMP13
SCHEMBL1246282 0.96 PPARD (0.49) PPARDMAPK14PPARGPPARAMMP13
SCHEMBL1746383 0.94 PPARD (0.47) PPARDPPARGPPARAMMP13MMP2
SCHEMBL1746387 0.94 PPARD (0.47) PPARDPPARGPPARAMMP13MMP2
SCHEMBL1746880 0.94 PPARD (0.47) PPARDPPARGPPARAMMP13MMP2
SCHEMBL1746386 0.94 PPARD (0.47) PPARDPPARGPPARAMMP13MMP2
SCHEMBL1746475 0.94 PPARD (0.47) PPARDPPARGPPARAMMP13MMP2
SCHEMBL1746477 0.94 PPARD (0.47) PPARDPPARGPPARAMMP13MMP2
SCHEMBL1744564 0.92 PPARD (0.46) PPARDPPARGPPARAMMP13MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2386540-A1 Novel compounds, their preparation and use High Point Pharmaceuticals, LLC (US) 2011-11-16 EP disclosed
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS HIGH POINT PHARMACEUTICALS, LLC (US) 2011-10-06 US disclosed
US-7943613-B2 Compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2011-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS PPARG, PPARA, PPARD PPARD 3/4885MAPK14 1302/4885PPARG 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.