SCHEMBL1747376

SCHEMBL1747376

Nc1cc(-c2cccc(-c3cccc(O)c3)c2)nc2c1C(=O)NCC2

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 18/20 0.73
MAPKAPK2 P49137 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1746603 0.85 PDE4B (0.69) PDE4B
SCHEMBL1746260 0.84 PDE4B (1.00) PDE4B
SCHEMBL1746675 0.84 PDE4B (0.74) PDE4B
SCHEMBL1747405 0.81 PDE4B (0.60) PDE4B
SCHEMBL1746152 0.79 PDE4B (0.67) PDE4B
SCHEMBL1747361 0.76 PDE4B (1.00) PDE4B
SCHEMBL1746289 0.76 PDE4B (1.00) PDE4B
SCHEMBL1746553 0.71 PDE4B (0.52) PDE4B
SCHEMBL3431816 0.69 CDC7 (0.53) PDE4BMAPKAPK2
SCHEMBL8442156 0.67 PDE4B (0.74) PDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2380890-A1 New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors Almirall, S.A. (ES) 2011-10-26 EP disclosed
EP-2380890-A1 New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors Almirall, S.A. (ES) 2011-10-26 EP disclosed
US-20110253549-A1 WASHING APPARATUS AND METHOD OF DEODORIZING WASHING WATER KANNO MINORU 2011-10-20 US disclosed