Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17477004 | 0.89 | PDE4B (0.44) | PDE4BROCK2PDE4D | |
| SCHEMBL17476951 | 0.85 | PDE4B (0.41) | PDE4BROCK2PDE4D | |
| SCHEMBL16179782 | 0.84 | PDE4B (0.46) | PDE4BPDE4D | |
| SCHEMBL16179393 | 0.82 | PDE4B (0.44) | PDE4BROCK2PDE4D | |
| SCHEMBL17477026 | 0.82 | PDE4B (0.44) | PDE4BPDE4D | |
| SCHEMBL17477025 | 0.82 | PDE4B (0.44) | PDE4BROCK2PDE4D | |
| SCHEMBL17477001 | 0.81 | PDE4B (0.43) | PDE4BPDE4D | |
| SCHEMBL17476990 | 0.77 | PDE4B (0.38) | PDE4B | |
| SCHEMBL17476917 | 0.75 | PDE4B (0.40) | PDE4BPDE4D | |
| SCHEMBL17476985 | 0.75 | GRIN2B (0.35) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2986600-B1 | SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2017-07-05 | — | — | EP | disclosed |
| US-9527832-B2 | Substituted condensed pyrimidine compounds | Grünenthal GmbH (DE) | 2016-12-27 | — | — | US | disclosed |
| US-20160031857-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031857-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | TYMP, PDE4A, DPYD | PDE4B 4/4885ROCK2 4033/4885PDE4D 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.