Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26989522 | 0.77 | GRM2 (0.47) | GRM2KCNH2CCR1CCR2 | |
| SCHEMBL26988136 | 0.77 | GRM2 (0.47) | GRM2KCNH2CCR1CCR2 | |
| SCHEMBL26988639 | 0.76 | GRM2 (0.45) | GRM2KCNH2CCR1CCR2 | |
| SCHEMBL26989401 | 0.76 | GRM2 (0.45) | GRM2KCNH2CCR1CCR2 | |
| SCHEMBL26987839 | 0.76 | GRM2 (0.41) | GRM2KCNH2CCR1CCR2CNR2 | |
| SCHEMBL26988205 | 0.76 | GRM2 (0.41) | GRM2KCNH2CCR1CCR2CNR2 | |
| SCHEMBL17480570 | 0.74 | GRM2 (0.61) | GRM2KCNH2 | |
| SCHEMBL17477940 | 0.74 | GRM2 (0.61) | GRM2KCNH2 | |
| SCHEMBL17490636 | 0.74 | GRM2 (0.61) | GRM2KCNH2 | |
| SCHEMBL18457759 | 0.73 | GRM2 (0.40) | GRM2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177623-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | Janssen Pharmaceutica, N.V. (BE) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016016380-A1 | 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |