Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | VHL | P40337 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17479511 | 1.00 | PIK3CD (0.62) | PIK3CDKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL17484861 | 1.00 | PIK3CD (0.62) | PIK3CDKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL17478597 | 1.00 | PIK3CD (0.62) | PIK3CDKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL18837802 | 1.00 | PIK3CD (0.62) | PIK3CDKDM4EMAPTKMT2AMEN1 | |
| SCHEMBL18837763 | 0.91 | PIK3CD (0.70) | PIK3CD | |
| SCHEMBL17484854 | 0.91 | PIK3CD (0.70) | PIK3CD | |
| SCHEMBL17478596 | 0.91 | PIK3CD (0.70) | PIK3CD | |
| SCHEMBL17478595 | 0.91 | PIK3CD (0.70) | PIK3CD | |
| SCHEMBL17479559 | 0.91 | PIK3CD (0.70) | PIK3CD | |
| SCHEMBL19711140 | 0.77 | PIK3CD (1.00) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174886-A1 | 2-OXA-5-AZABICYCLO[2.2.1]HEPTAN-3-YL DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2017-06-07 | — | — | EP | disclosed |
| WO-2016015333-A1 | 2-OXA-5-AZABICYCLO [2.2.1] HEPTAN-3-YL DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016292-A1 | 2-OXA-5-AZABICYCLO[2.2.1]HEPTAN-3-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-02-04 | — | — | WO | disclosed |