Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | SPPL2A | Q8TCT8 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17479006 | 0.90 | SMN1; SMN2 (0.43) | MAPK1TSHRHSD17B10MAPTKDM4E | |
| SCHEMBL17479705 | 0.88 | HSD17B10 (0.42) | MAPK1TSHRHSD17B10MAPTTHRB | |
| SCHEMBL17479172 | 0.88 | SMN1; SMN2 (0.42) | MAPK1TSHRHSD17B10MAPTKDM4E | |
| SCHEMBL17479698 | 0.85 | SMN1; SMN2 (0.44) | MAPK1TSHRHSD17B10MAPTKDM4E | |
| SCHEMBL17479324 | 0.82 | TSHR (0.38) | MAPK1TSHRHSD17B10PSEN1PSEN2 | |
| SCHEMBL17479795 | 0.82 | SMN1; SMN2 (0.45) | MAPK1TSHRHSD17B10MAPTKDM4E | |
| SCHEMBL17479707 | 0.81 | PSEN1 (0.39) | MAPK1TSHRHSD17B10PSEN1PSEN2 | |
| SCHEMBL17479791 | 0.81 | KDM4E (0.42) | MAPK1HSD17B10MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL17479726 | 0.80 | TSHR (0.41) | MAPK1TSHRHSD17B10MAPTTHRB | |
| SCHEMBL17479057 | 0.77 | PARP3 (0.46) | MAPK1HSD17B10MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174859-B1 | FLT3 RECEPTOR ANTAGONISTS | INST NAT SANTE RECH MED (FR) | 2020-04-29 | — | — | EP | claimed |
| US-10065937-B2 | FLT3 receptor antagonists | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2018-09-04 | — | — | US | claimed |
| US-20170233354-A1 | FLT3 RECEPTOR ANTAGONISTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2017-08-17 | — | — | US | claimed |
| EP-3174859-A1 | FLT3 RECEPTOR ANTAGONISTS | INSERM - Institut National de la Santé et de la Recherche Médicale (FR) | 2017-06-07 | — | — | EP | claimed |
| WO-2016016370-A1 | FLT3 RECEPTOR ANTAGONISTS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2016-02-04 | — | — | WO | claimed |
| CN-107001283-B | FLT3 receptor antagonists | 国家健康与医学研究院 | 2021-05-25 | — | — | CN | disclosed |
| US-20200171022-A1 | FLT3 INHIBITORS FOR IMPROVING PAIN TREATMENTS BY OPIOIDS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-06-04 | — | — | US | disclosed |
| CN-111093640-A | FLT3 inhibitors for improving opioid pain therapy | 国家健康与医学研究院 | 2020-05-01 | — | — | CN | disclosed |
| EP-3174859-B1 | FLT3 RECEPTOR ANTAGONISTS | INST NAT SANTE RECH MED (FR) | 2020-04-29 | — | — | EP | disclosed |
| EP-3624780-A1 | FLT3 INHIBITORS FOR IMPROVING PAIN TREATMENTS BY OPIOIDS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-03-25 | — | — | EP | disclosed |
| WO-2018211018-A1 | FLT3 INHIBITORS FOR IMPROVING PAIN TREATMENTS BY OPIOIDS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2018-11-22 | — | — | WO | disclosed |
| US-10065937-B2 | FLT3 receptor antagonists | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2018-09-04 | — | — | US | disclosed |
| US-20170233354-A1 | FLT3 RECEPTOR ANTAGONISTS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2017-08-17 | — | — | US | disclosed |
| EP-3174859-A1 | FLT3 RECEPTOR ANTAGONISTS | INSERM - Institut National de la Santé et de la Recherche Médicale (FR) | 2017-06-07 | — | — | EP | disclosed |
| WO-2016016370-A1 | FLT3 RECEPTOR ANTAGONISTS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2016-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170233354-A1 | FLT3 RECEPTOR ANTAGONISTS | FLT3, CSF1R, CSF3R | MAPK1 1387/4885TSHR 69/4885HSD17B10 4204/4885 |
| US-10065937-B2 | FLT3 receptor antagonists | FLT3, CSF1R, CSF3R | MAPK1 1387/4885TSHR 69/4885HSD17B10 4204/4885 |
| US-20200171022-A1 | FLT3 INHIBITORS FOR IMPROVING PAIN TREATMENTS BY OPIOIDS | FLT3, CSF1R, OPRL1 | MAPK1 601/4885TSHR 2361/4885HSD17B10 4833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.