Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 12/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17484017 | 0.81 | HDAC6 (0.49) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL19666164 | 0.77 | HDAC6 (0.74) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL16653762 | 0.77 | HDAC6 (0.74) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL16653760 | 0.77 | HDAC6 (0.74) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL22332723 | 0.75 | HDAC6 (0.67) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL17483993 | 0.74 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL19682894 | 0.73 | HDAC3 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL24293742 | 0.72 | HDAC3 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL20683105 | 0.72 | HDAC3 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL14600330 | 0.71 | CA12 (0.55) | HDAC3HDAC1HDAC2HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016018795-A1 | HISTONE DEACETYLASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2016-02-04 | — | — | WO | disclosed |