Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17484160 | 0.99 | KDR (0.52) | KDRPDGFRBMAPTNPSR1AKR1C3 | |
| SCHEMBL17590016 | 0.87 | KDR (0.58) | KDRPDGFRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL17484153 | 0.83 | KDR (0.68) | KDRPDGFRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL17484158 | 0.83 | KDR (0.78) | KDRPDGFRB | |
| SCHEMBL17484151 | 0.82 | KDR (0.78) | KDRPDGFRB | |
| SCHEMBL17590015 | 0.80 | KDR (0.57) | KDRPDGFRB | |
| SCHEMBL17484163 | 0.80 | MEN1 (0.55) | KDRPDGFRBMAPTNPSR1KDM4E | |
| SCHEMBL17484155 | 0.78 | KDR (0.69) | KDRPDGFRB | |
| SCHEMBL17484161 | 0.77 | KDR (0.67) | KDRPDGFRBKDM4EMEN1ALDH1A1 | |
| SCHEMBL15238385 | 0.75 | KDR (0.69) | KDRPDGFRBKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255096-B1 | Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2016-02-09 | — | — | US | claimed |
| US-9255096-B1 | Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2016-02-09 | — | — | US | disclosed |