Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | AURKA | O14965 | 5/20 | 0.52 |
| ▸ | FLT1 | P17948 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | MELK | Q14680 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077439 | 0.93 | FLT3 (0.49) | FLT3KDRAURKAFLT1MELK | |
| SCHEMBL12077944 | 0.93 | FLT3 (0.54) | FLT3KDRAURKAFLT1KIT | |
| SCHEMBL12077998 | 0.91 | HDAC1 (0.55) | FLT3KDRFLT1KITHDAC1 | |
| SCHEMBL12077467 | 0.90 | FLT3 (0.50) | FLT3KDRAURKAFLT1KIT | |
| SCHEMBL12077710 | 0.90 | FLT3 (0.50) | FLT3KDRAURKAFLT1KIT | |
| SCHEMBL12077320 | 0.89 | FLT3 (0.53) | FLT3KDRAURKAFLT1KDM1A | |
| SCHEMBL12077927 | 0.87 | KDM1A (0.64) | FLT3KDRAURKAFLT1KDM1A | |
| SCHEMBL12077119 | 0.86 | FLT3 (0.52) | FLT3KDRAURKAFLT1KIT | |
| SCHEMBL12091918 | 0.85 | FLT3 (0.52) | FLT3KDRAURKAFLT1KDM1A | |
| SCHEMBL12091914 | 0.85 | NPC1 (0.67) | FLT3KDRAURKAFLT1MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255072-B2 | Pyrazole compounds and thiazole compounds as protein kinases inhibitors | National Health Rsearch Institutes (TW) | 2016-02-09 | — | — | US | disclosed |