Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.62 |
| ▸ | CDK6 | Q00534 | 16/20 | 0.62 |
| ▸ | CCND3 | P30281 | 10/20 | 0.62 |
| ▸ | CCND1 | P24385 | 9/20 | 0.62 |
| ▸ | CDK2 | P24941 | 8/20 | 0.58 |
| ▸ | CDK1 | P06493 | 4/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17477193 | 0.91 | CDK4 (0.62) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17485357 | 0.88 | CDK4 (0.63) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17485352 | 0.87 | CDK4 (0.59) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17485363 | 0.86 | CDK4 (0.61) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17485420 | 0.86 | CDK4 (0.66) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17485368 | 0.86 | CDK4 (0.62) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17485365 | 0.85 | CDK4 (0.57) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17488630 | 0.85 | CDK4 (0.61) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17488699 | 0.85 | CDK4 (0.61) | CDK4CDK6CCND3CCND1CDK2 | |
| SCHEMBL17485354 | 0.84 | CDK4 (0.65) | CDK4CDK6CCND3CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016015604-A1 | COMPOUNDS AS CDK SMALL-MOLECULE INHIBITORS AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-02-04 | — | — | WO | disclosed |