Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 | Q05940 | 11/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.71 |
| ▸ | HTR2A | P28223 | 3/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | DRD1 | P21728 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | HTR1D | P28221 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9872201 | 0.88 | SLC18A2 (0.68) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL17485180 | 0.86 | SLC18A2 (0.78) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL17474550 | 0.86 | SLC18A2 (0.78) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL17485203 | 0.85 | SLC18A2 (0.84) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL17474575 | 0.84 | SLC18A2 (0.72) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL19483241 | 0.83 | SLC18A2 (1.00) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL17486597 | 0.83 | SLC18A2 (1.00) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL17474531 | 0.83 | SLC18A2 (1.00) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL17477247 | 0.83 | SLC18A2 (1.00) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 | |
| SCHEMBL17486601 | 0.83 | SLC18A2 (1.00) | SLC18A2SLC6A3HTR2AKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546151-B2 | VMAT inhibitory compounds | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2017-01-17 | — | — | US | disclosed |
| US-20160031852-A1 | VMAT INHIBITORY COMPOUNDS | WILMINGTON TRUST (LONDON) LIMITED, AS SECURITY AGENT (GB) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031852-A1 | VMAT INHIBITORY COMPOUNDS | SLC18A2, SLC18A3, SLC6A2 | SLC18A2 1/4885SLC6A3 4/4885HTR2A 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.