Sugi Predict

Sugi Predict / Compounds / SCHEMBL1748711

SCHEMBL1748711

SCHEMBL1748711

COc1cc2c(-c3cc4cccnc4n3S(=O)(=O)c3ccc(C)cc3)cn(C)c2cc1OCCN1CCOCC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.40
▸ ALDH1A1 P00352 2/20 0.40
▸ IGF1R P08069 1/20 0.40
▸ EGFR P00533 3/20 0.39
▸ BRD4 O60885 1/20 0.39
▸ NPC1 O15118 1/20 0.38
▸ USP2 O75604 1/20 0.38
▸ SRC P12931 4/20 0.38
▸ KDR P35968 4/20 0.38
▸ KIT P10721 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ LCK P06239 2/20 0.38
▸ PDPK1 O15530 1/20 0.38
▸ EPHA2 P29317 1/20 0.37
▸ EPHB4 P54760 1/20 0.37
▸ SYK P43405 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1748867 0.90 IGF1R (0.39) IGF1RKDR
SCHEMBL1780587 0.90 KMT2A (0.40) KMT2AALDH1A1EGFRNPC1USP2
SCHEMBL1749119 0.88 IGF1R (0.44) ALDH1A1IGF1RGAAPDPK1
SCHEMBL1778785 0.88 IGF1R (0.50) KMT2AALDH1A1IGF1RKDM4EHPGD
SCHEMBL1748634 0.87 IGF1R (0.44) ALDH1A1IGF1RGAA
SCHEMBL1748899 0.87 IGF1R (0.44) ALDH1A1IGF1RGAA
SCHEMBL1749000 0.87 IGF1R (0.44) ALDH1A1IGF1RGAA
SCHEMBL1749120 0.87 IGF1R (0.44) ALDH1A1IGF1RGAA
SCHEMBL1749102 0.85 IGF1R (0.42) KMT2AALDH1A1IGF1REGFRKDM4E
SCHEMBL1748833 0.84 IGF1R (0.42) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968566-B2 Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors AVENTIS PHARMA S.A. (FR) 2011-06-28 — — US disclosed
US-20090233956-A1 NOVEL PYRROLO(2,3-b) PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2009-09-17 — — US disclosed
US-7528147-B2 Pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors AVENTIS PHARMA S.A. (FR) 2009-05-05 — — US disclosed
US-20070093480-A1 Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors AVENTIS PHARMA S.A. (FR) 2007-04-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090233956-A1 NOVEL PYRROLO(2,3-b) PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS MAP3K19, MAP4K2, MAP3K1 KMT2A 1929/4885ALDH1A1 3780/4885IGF1R 817/4885
US-20070093480-A1 Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors MAP3K19, MAP4K2, MAP3K1 KMT2A 1929/4885ALDH1A1 3780/4885IGF1R 817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.