Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 10/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.39 |
| ▸ | PAK4 | O96013 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17487531 | 0.89 | PLK4 (0.41) | PLK4NTRK1PAK4JAK2JAK3 | |
| SCHEMBL17488023 | 0.87 | CYP3A4 (0.47) | PLK4NTRK1PAK4NPC1RAB9A | |
| SCHEMBL17488243 | 0.85 | PLK4 (0.42) | PLK4NTRK1PAK4JAK2JAK3 | |
| SCHEMBL18965934 | 0.84 | GSK3B (0.40) | PLK4NTRK1PAK4JAK2JAK3 | |
| SCHEMBL17488019 | 0.82 | PLK4 (0.42) | PLK4NTRK1PAK4RETNPC1 | |
| SCHEMBL18965980 | 0.82 | NTRK1 (0.47) | PLK4NTRK1PAK4JAK2JAK3 | |
| SCHEMBL18965308 | 0.82 | DHODH (0.44) | PLK4NTRK1KDRNPC1RAB9A | |
| SCHEMBL17487841 | 0.80 | DHODH (0.43) | PLK4NTRK1JAK2JAK3AURKA | |
| SCHEMBL17488030 | 0.79 | PLK4 (0.46) | PLK4NTRK1PAK4JAK2JAK3 | |
| SCHEMBL17488026 | 0.79 | NTRK1 (0.47) | PLK4NTRK1PAK4JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016421-A1 | 2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS | INSTITUT PASTEUR KOREA (KR) | 2016-02-04 | — | — | WO | disclosed |