SCHEMBL17488910

SCHEMBL17488910

Cc1nc2ccc(-c3nc(Nc4ccc(N5CC(O)C5)cn4)ncc3F)cc2n1C(C)C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK6 Q00534 17/20 0.56
CDK4 P11802 11/20 0.56
CCND1 P24385 9/20 0.56
CDK1 P06493 4/20 0.56
CCNB1 P14635 3/20 0.56
CCND3 P30281 3/20 0.56
PIM1 P11309 3/20 0.53
CCNA2 P20248 3/20 0.53
HDAC1 Q13547 1/20 0.52
CDK2 P24941 3/20 0.51
CDK9 P50750 3/20 0.51
CCNT1 O60563 2/20 0.51
CCNE1 P24864 2/20 0.51
CDK5 Q00535 2/20 0.51
KCNH2 Q12809 2/20 0.51
CDK5R1 Q15078 2/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
CCNK O75909 2/20 0.50
CSF1R P07333 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17488977 0.90 CDK6 (0.58) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17489279 0.90 CDK6 (0.58) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17488939 0.90 CDK6 (0.58) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17477188 0.89 CDK4 (0.63) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17488844 0.87 CDK6 (0.66) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17488843 0.87 CDK6 (0.66) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17488830 0.86 CDK6 (0.61) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17488894 0.85 CDK6 (0.58) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17489095 0.82 CDK6 (0.61) CDK6CDK4CCND1CDK1CCNB1
SCHEMBL17489296 0.82 CDK4 (0.61) CDK6CDK4CCND1CDK1CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016015605-A1 COMPOUNDS AS CDK SMALL-MOLECULE INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-02-04 WO disclosed