Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 5/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21810986 | 0.97 | CHRM2 (0.39) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| SCHEMBL28508058 | 0.95 | CHRM2 (0.38) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| SCHEMBL10942478 | 0.79 | CYP1A2 (0.41) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| SCHEMBL14463009 | 0.78 | CYP1A2 (0.33) | CHRM2CHRM1CYP2D6KCNH2CYP1A2 | |
| Methane SCHEMBL28302061 | 0.77 | CYP1A2 (0.39) | CHRM2CHRM1CYP2D6KCNH2CHRM3 | |
| Alcohol SCHEMBL28368399 | 0.77 | CYP1A2 (0.34) | CHRM2CHRM1CYP2D6KCNH2CYP1A2 | |
| SCHEMBL2580716 | 0.76 | CYP1A2 (0.37) | CHRM2CHRM1CYP2D6KCNH2CYP1A2 | |
| SCHEMBL10234483 | 0.76 | CYP1A2 (0.37) | CHRM2CHRM1CYP2D6KCNH2CYP1A2 | |
| SCHEMBL14048439 | 0.76 | CYP1A2 (0.32) | CHRM2CHRM1CYP2D6KCNH2CYP1A2 | |
| SCHEMBL10876431 | 0.74 | CYP1A2 (0.36) | CHRM2CHRM1CYP2D6KCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160031868-A1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | GILEAD SCIENCES, INC. | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031868-A1 | BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | CHRM2 2750/4885CHRM1 1871/4885CYP2D6 4088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.