Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 20/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17490724 | 0.89 | GRM2 (0.72) | GRM2 | |
| SCHEMBL17480531 | 0.88 | GRM2 (0.71) | GRM2 | |
| SCHEMBL17480555 | 0.87 | GRM2 (0.69) | GRM2 | |
| SCHEMBL17810193 | 0.87 | GRM2 (0.69) | GRM2 | |
| SCHEMBL17478257 | 0.87 | GRM2 (0.69) | GRM2 | |
| SCHEMBL20751732 | 0.87 | GRM2 (0.72) | GRM2 | |
| SCHEMBL16397824 | 0.86 | GRM2 (1.00) | GRM2 | |
| SCHEMBL17485465 | 0.86 | GRM2 (0.71) | GRM2 | |
| SCHEMBL17484573 | 0.86 | GRM2 (0.68) | GRM2 | |
| SCHEMBL17485446 | 0.86 | GRM2 (0.68) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016395-A1 | 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-02-04 | — | — | WO | disclosed |