Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 4/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 3/20 | 0.36 |
| ▸ | TACR3 | P29371 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.35 |
| ▸ | ITGAL | P20701 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17491500 | 0.94 | PRKD1 (0.39) | METAP2SLC6A3GABRA1IDH2RAF1 | |
| SCHEMBL17491454 | 0.84 | MAP3K12 (0.37) | METAP2RHOAAKT1PIK3CAMTOR | |
| SCHEMBL17491528 | 0.82 | AKT1 (0.38) | METAP2RHOAAKT1PIK3CAMTOR | |
| SCHEMBL17491552 | 0.82 | SYK (0.47) | RHOAITGB2ICAM1ITGAL | |
| SCHEMBL17491511 | 0.81 | RHOA (0.33) | METAP2SLC6A3GABRA1RHOAAKT1 | |
| SCHEMBL17491485 | 0.81 | HPGD (0.43) | METAP2SLC6A3GABRA1IDH2RAF1 | |
| SCHEMBL17491550 | 0.80 | NPSR1 (0.42) | METAP2IDH2RAF1BRAF | |
| SCHEMBL17491391 | 0.80 | SMO (0.46) | RHOAAKT1 | |
| SCHEMBL17491532 | 0.79 | RHOA (0.40) | METAP2SLC6A3GABRA1IDH2RHOA | |
| SCHEMBL17491466 | 0.79 | RHOA (0.40) | METAP2SLC6A3GABRA1IDH2RHOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2982670-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2018-11-07 | — | — | EP | disclosed |
| US-9624184-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-04-18 | — | — | US | disclosed |
| US-9624184-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-04-18 | — | — | US | disclosed |
| US-9624184-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-04-18 | — | — | US | disclosed |
| US-20160052897-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-02-25 | — | — | US | disclosed |
| EP-2982670-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2016-02-10 | — | — | EP | disclosed |
| EP-2982670-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2016-02-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052897-A1 | HETEROCYCLIC COMPOUND | PSEN1, PSEN2, BACE1 | METAP2 2639/4885SLC6A3 2689/4885GABRA1 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.