⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1741742 | 0.80 | — | — | |
| SCHEMBL31050959 | 0.78 | — | — | |
| SCHEMBL27601581 | 0.71 | — | — | |
| SCHEMBL6582970 | 0.71 | — | — | |
| SCHEMBL28071221 | 0.70 | — | — | |
| SCHEMBL28257312 | 0.70 | — | — | |
| SCHEMBL28830794 | 0.69 | — | — | |
| SCHEMBL29092388 | 0.68 | — | — | |
| SCHEMBL7014854 | 0.67 | — | — | |
| SCHEMBL27641253 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10618892-B2 | Processes for the preparation of a BACE inhibitor | MERCK SHARP & DOHME CORP. (US) | 2020-04-14 | — | — | US | disclosed |
| US-20200039975-A1 | PROCESSES FOR THE PREPARATION OF A BACE INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2020-02-06 | — | — | US | disclosed |
| EP-3416648-A1 | PROCESSES FOR THE PREPARATION OF A BACE INHIBITOR | Merck Sharp & Dohme Corp. (US) | 2018-12-26 | — | — | EP | disclosed |
| WO-2017142804-A1 | PROCESSES FOR THE PREPARATION OF A BACE INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2017-08-24 | — | — | WO | disclosed |
| US-20170233382-A1 | PROCESSES FOR THE PREPARATION OF A BACE INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2017-08-17 | — | — | US | disclosed |
| WO-2016025359-A1 | PROCESSES FOR THE PREPARATION OF A BACE INHIBITOR | MERCK SHARP & DOHME CORP. (US) | 2016-02-18 | — | — | WO | disclosed |