Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14746276 | 0.90 | EGLN1 (0.40) | MAPTPOLBTDP1TSHREGLN1 | |
| SCHEMBL14745862 | 0.90 | EGLN1 (0.40) | MAPTPOLBTDP1TSHREGLN1 | |
| SCHEMBL17495073 | 0.81 | EGLN1 (0.38) | EGLN1ALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL14741316 | 0.80 | EGLN1 (0.39) | MAPTPOLBTDP1TSHREGLN1 | |
| SCHEMBL14745744 | 0.80 | EGLN1 (0.39) | MAPTPOLBTSHREGLN1ALDH1A1 | |
| SCHEMBL14745965 | 0.80 | EGLN1 (0.39) | MAPTPOLBTDP1TSHREGLN1 | |
| SCHEMBL14746011 | 0.80 | EGLN1 (0.42) | TSHREGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL14745710 | 0.79 | EGLN1 (0.37) | MAPTPOLBTDP1TSHREGLN1 | |
| SCHEMBL14746181 | 0.79 | EGLN1 (0.37) | MAPTPOLBTSHREGLN1ALDH1A1 | |
| SCHEMBL17895953 | 0.79 | HPGD (0.42) | MAPTPOLBTDP1TSHREGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016025932-A1 | SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |