Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 5/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60743 | 0.80 | CRBN (0.67) | GSPT1DDB1CRBNIKZF3 | |
| SCHEMBL26100972 | 0.80 | ESR2 (0.56) | ESR2NPC1RAB9ANR1H2PIK3CA | |
| SCHEMBL7019447 | 0.79 | CRBN (0.58) | ESR2NPC1RAB9AGSPT1DDB1 | |
| SCHEMBL17495165 | 0.74 | ESR2 (0.48) | ESR2NPC1RAB9ADDB1CRBN | |
| SCHEMBL1187991 | 0.73 | NPC1 (0.54) | ESR2NPC1RAB9ANR1H2PIK3CA | |
| SCHEMBL1188104 | 0.73 | ESR2 (0.61) | ESR2NPC1RAB9ANR1H2PIK3CA | |
| SCHEMBL1188295 | 0.72 | ESR2 (0.63) | ESR2NPC1RAB9ANR1H2PIK3CA | |
| SCHEMBL1187860 | 0.72 | ESR2 (0.62) | ESR2NPC1RAB9ANR1H2PIK3CA | |
| SCHEMBL1188540 | 0.72 | ESR2 (0.62) | ESR2NPC1RAB9ANR1H2PIK3CA | |
| SCHEMBL31174286 | 0.71 | ESR2 (0.67) | ESR2NPC1RAB9ANR1H2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2985281-A2 | ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Celgene Corporation (US) | 2016-02-17 | — | — | EP | disclosed |