Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27990722 | 0.91 | HSD17B10 (0.38) | KMT2AMAPTLMNAF2SMN1; SMN2 | |
| SCHEMBL28015157 | 0.89 | HSD17B10 (0.37) | KMT2AMAPTLMNAF2SMN1; SMN2 | |
| SCHEMBL28050875 | 0.88 | KMT2A (0.37) | KMT2AMAPTSMN1; SMN2TSHRKDM4E | |
| SCHEMBL28054634 | 0.88 | TSHR (0.41) | KMT2AMAPTSMN1; SMN2TSHRHPGD | |
| SCHEMBL28065967 | 0.86 | TSHR (0.40) | KMT2AMAPTLMNASMN1; SMN2TSHR | |
| SCHEMBL28044876 | 0.86 | TSHR (0.40) | KMT2AMAPTLMNASMN1; SMN2TSHR | |
| SCHEMBL28013539 | 0.86 | TSHR (0.40) | KMT2AMAPTLMNASMN1; SMN2TSHR | |
| SCHEMBL28005995 | 0.86 | TSHR (0.40) | KMT2AMAPTLMNASMN1; SMN2TSHR | |
| Naphthalene SCHEMBL28011212 | 0.84 | KMT2A (0.43) | KMT2AMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL28064662 | 0.84 | CA12 (0.39) | KMT2AMAPTLMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107325284-B | Hyperbranched polyphenyl triazole formate as well as preparation method and application thereof | 苏州大学 | 2020-01-14 | — | — | CN | claimed |
| CN-107325284-A | A kind of hyperbranched poly phenyl triazole formic acid esters and preparation method and application | 苏州大学 | 2017-11-07 | — | — | CN | claimed |
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |
| CN-109438700-B | Polymethyl triazole formate and preparation method and application thereof | 苏州大学 | 2021-06-18 | — | — | CN | disclosed |
| EP-3177616-B1 | NOVEL ROUTES OF SYNTHESIS FOR THE PREPARATION OF SUVOREXANT | SANDOZ AG (CH) | 2021-02-24 | — | — | EP | disclosed |
| CN-106573882-B | Synthetic route to suvorexant | 桑多斯股份公司 | 2020-09-01 | — | — | CN | disclosed |
| CN-107325284-B | Hyperbranched polyphenyl triazole formate as well as preparation method and application thereof | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-107325284-B | Hyperbranched polyphenyl triazole formate as well as preparation method and application thereof | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| CN-107325284-B | Hyperbranched polyphenyl triazole formate as well as preparation method and application thereof | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| US-10030010-B2 | Route of synthesis for the preparation of suvorexant | SANDOZ AG (CH) | 2018-07-24 | — | — | US | disclosed |
| CN-107325284-A | A kind of hyperbranched poly phenyl triazole formic acid esters and preparation method and application | 苏州大学 | 2017-11-07 | — | — | CN | disclosed |
| US-20170217947-A1 | Novel Route of Synthesis for the Preparation of Suvorexant | SANDOZ AG (CH) | 2017-08-03 | — | — | US | disclosed |
| EP-3177616-A1 | NOVEL ROUTES OF SYNTHESIS FOR THE PREPARATION OF SUVOREXANT | Sandoz AG (CH) | 2017-06-14 | — | — | EP | disclosed |
| CN-106573882-A | Novel routes of synthesis for preparation of suvorexant | 桑多斯股份公司 | 2017-04-19 | — | — | CN | disclosed |
| WO-2016020406-A1 | NOVEL ROUTES OF SYNTHESIS FOR THE PREPARATION OF SUVOREXANT | SANDOZ AG (CH) | 2016-02-11 | — | — | WO | disclosed |
| WO-2016020405-A1 | NOVEL ROUTES OF SYNTHESIS FOR THE PREPARATION OF SUVOREXANT | SANDOZ AG (CH) | 2016-02-11 | — | — | WO | disclosed |
| CN-1042236-C | Liquid detergent compositions | PROCTER & GAMBLE (US) | 1999-02-24 | — | — | CN | disclosed |
| CN-1062160-A | Liquid detergent composition | PROCTER & GAMBLE (US) | 1992-06-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217947-A1 | Novel Route of Synthesis for the Preparation of Suvorexant | CYP51A1, CYP3A5, HCRTR2 | KMT2A 199/4885MAPT 663/4885LMNA 3937/4885 |
| US-10030010-B2 | Route of synthesis for the preparation of suvorexant | CYP51A1, CYP3A5, HCRTR2 | KMT2A 175/4885MAPT 687/4885LMNA 3768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.