Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 6/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28209057 | 0.85 | PRCP (0.71) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL1012767 | 0.78 | PRCP (1.00) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL31158625 | 0.78 | PRCP (1.00) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL29768316 | 0.78 | PRCP (1.00) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL24091985 | 0.78 | PRCP (1.00) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL31569038 | 0.77 | PRCP (0.77) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL11536627 | 0.76 | PRCP (0.65) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL24845654 | 0.74 | PRCP (0.71) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL4144168 | 0.74 | PRCP (0.71) | PRCPTSHRNPSR1SLC22A1GAA | |
| SCHEMBL3235313 | 0.72 | PRCP (0.51) | PRCPTSHRNPSR1SLC22A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618129-B2 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2013-12-31 | — | — | US | disclosed |
| EP-2611780-A1 | SUBSTITUTED 1-OXO-DIHYDROISOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028300-A1 | SUBSTITUTED 1-OXO-DIHYDROISOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-03-08 | — | — | WO | disclosed |
| US-20120053203-A1 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | GRUNENTHAL GMBH (DE) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053203-A1 | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators | KCNQ1, KCNQ2, KCNQ3 | PRCP 4053/4885TSHR 4213/4885NPSR1 1303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.