Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHH | Q15465 | 7/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17497675 | 1.00 | SHH (0.61) | SHHUSP2AGTR1L3MBTL1ALDH1A1 | |
| SCHEMBL17497510 | 0.92 | SHH (0.60) | SHHUSP2AGTR1L3MBTL1 | |
| SCHEMBL17497507 | 0.92 | SHH (0.60) | SHHUSP2AGTR1L3MBTL1 | |
| SCHEMBL17515417 | 0.91 | SHH (0.59) | SHHUSP2AGTR1L3MBTL1 | |
| SCHEMBL17497985 | 0.90 | SHH (0.58) | SHHUSP2AGTR1 | |
| SCHEMBL17497987 | 0.90 | SHH (0.58) | SHHUSP2AGTR1 | |
| SCHEMBL17515418 | 0.88 | SHH (0.56) | SHHUSP2AGTR1 | |
| SCHEMBL2188428 | 0.86 | SHH (0.69) | SHHUSP2AGTR1L3MBTL1 | |
| SCHEMBL2188419 | 0.86 | SHH (0.69) | SHHUSP2AGTR1L3MBTL1 | |
| SCHEMBL17497774 | 0.82 | SHH (0.70) | SHHUSP2AGTR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160046590-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INST TECHNOLOGY (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046590-A1 | SONIC HEDGEHOG MODULATORS | SHH, GLI1, SMO | SHH 1/4885USP2 234/4885AGTR1 4594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.