SCHEMBL17499704

SCHEMBL17499704

Cn1c(C=Nc2ccccc2O[Si](C)(C)C)nc2ccccc21

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 9/20 0.54
TP53 P04637 2/20 0.51
ALOX15 P16050 1/20 0.51
TSHR P16473 1/20 0.51
ALDH1A1 P00352 8/20 0.49
HPGD P15428 4/20 0.49
HSD17B10 Q99714 1/20 0.49
GAA P10253 2/20 0.46
POLB P06746 3/20 0.46
HTT P42858 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
MAPT P10636 5/20 0.46
NPC1 O15118 5/20 0.46
RAB9A P51151 5/20 0.46
KMT2A Q03164 3/20 0.46
PKM P14618 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
LMNA P02545 3/20 0.44
CYP1A2 P05177 2/20 0.44
CYP3A4 P08684 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16102634 0.88 KDM4E (0.49) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL16102637 0.88 KDM4E (0.49) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL16103529 0.87 KDM4E (0.48) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL16103526 0.87 KDM4E (0.48) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL16101976 0.86 KDM4E (0.56) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL814116 0.86 KDM4E (0.56) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL16102752 0.84 KDM4E (0.50) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL16102756 0.84 KDM4E (0.50) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL16103565 0.83 GAA (0.49) KDM4ETP53ALOX15TSHRALDH1A1
SCHEMBL16103568 0.83 GAA (0.49) KDM4ETP53ALOX15TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed