Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 4/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17500223 | 1.00 | NR1H4 (0.51) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| SCHEMBL18572547 | 0.87 | NR1H4 (0.49) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| SCHEMBL7910940 | 0.87 | NR1H4 (0.49) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| SCHEMBL7910941 | 0.87 | NR1H4 (0.49) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| SCHEMBL27645996 | 0.86 | NR1H4 (0.48) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| Hydrochloric Acid SCHEMBL3937287 | 0.85 | NR1H4 (0.48) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| Hydrochloric Acid SCHEMBL3937294 | 0.85 | NR1H4 (0.48) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| SCHEMBL4679564 | 0.85 | NR1H4 (0.50) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| SCHEMBL4679570 | 0.85 | NR1H4 (0.50) | NR1H4AKR1B10AKR1B1PKMKDM4E | |
| SCHEMBL10509071 | 0.84 | TTR (0.53) | NR1H4AKR1B10AKR1B1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177621-B1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIV REGENSBURG (DE) | 2021-11-10 | — | — | EP | disclosed |
| US-10106540-B2 | HDAC6 inhibitors and their uses | UNIVERSITÄT REGENSBURG (DE) | 2018-10-23 | — | — | US | disclosed |
| US-20170210743-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | Universitätsklinikum Jena (DE) | 2017-07-27 | — | — | US | disclosed |
| EP-3177621-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | Universität Regensburg (DE) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016020369-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIVERSITÄT REGENSBURG (DE) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210743-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | HDAC6, HDAC5, HDAC4 | NR1H4 517/4885AKR1B10 1713/4885AKR1B1 1896/4885 |
| US-10106540-B2 | HDAC6 inhibitors and their uses | HDAC6, HDAC5, HDAC4 | NR1H4 506/4885AKR1B10 1649/4885AKR1B1 1781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.