Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 15/20 | 0.61 |
| ▸ | HTR6 | P50406 | 14/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | HTR7 | P34969 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17502092 | 0.90 | HRH1 (0.61) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL12480265 | 0.87 | HRH1 (0.63) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL176759 | 0.84 | HRH1 (0.66) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL168755 | 0.84 | HRH1 (0.69) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL169624 | 0.84 | HRH1 (0.61) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL13834437 | 0.83 | HRH1 (0.62) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL176200 | 0.82 | HRH1 (0.69) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL16638444 | 0.82 | HRH1 (0.61) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL12479326 | 0.81 | HRH1 (0.58) | HRH1HTR6GRIN1GRIN2AGRIN2B | |
| SCHEMBL13834421 | 0.81 | HRH1 (0.65) | HRH1HTR6GRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424366-B1 | PYRIDO [4, 3-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES INC (US) | 2016-02-17 | — | — | EP | claimed |