Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 8/20 | 0.40 |
| ▸ | KDM5A | P29375 | 11/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17507051 | 0.85 | MAP3K12 (0.45) | MAP3K12TLR9TLR8TLR7 | |
| SCHEMBL17507029 | 0.80 | MAP3K12 (0.51) | MAP3K12 | |
| SCHEMBL17507050 | 0.79 | MAP3K12 (0.55) | MAP3K12 | |
| SCHEMBL17507055 | 0.78 | MAP3K12 (0.58) | MAP3K12 | |
| SCHEMBL17507059 | 0.76 | MAP3K12 (0.60) | MAP3K12TLR8TLR7 | |
| SCHEMBL16220056 | 0.75 | MAP3K12 (0.69) | MAP3K12 | |
| SCHEMBL17507010 | 0.73 | MAP3K12 (0.51) | MAP3K12 | |
| SCHEMBL17507062 | 0.71 | MAP3K12 (0.55) | MAP3K12 | |
| SCHEMBL17507022 | 0.71 | MAP3K12 (0.49) | MAP3K12 | |
| SCHEMBL17507073 | 0.70 | MAP3K12 (0.51) | MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868720-B2 | C-linked heterocycloaklyl substituted pyrimidines and their uses | GENENTECH, INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160046608-A1 | C-Linked Heterocycloaklyl Substituted Pyrimidines and their uses | GENENTECH, INC. (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046608-A1 | C-Linked Heterocycloaklyl Substituted Pyrimidines and their uses | TYMS, DPYD, TYMP | MAP3K12 1825/4885KDM5A 2340/4885TLR9 2769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.