Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 20/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 13/20 | 1.00 |
| ▸ | GRK5 | P34947 | 14/20 | 0.79 |
| ▸ | GRK1 | Q15835 | 4/20 | 0.79 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.77 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17525385 | 0.92 | GRK2 (1.00) | GRK2ROCK1GRK5GRK1RPS6KB1 | |
| SCHEMBL2567101 | 0.91 | GRK2 (0.84) | GRK2ROCK1GRK5GRK1RPS6KB1 | |
| SCHEMBL2567227 | 0.90 | GRK2 (0.81) | GRK2ROCK1GRK5GRK1RPS6KB1 | |
| SCHEMBL2568612 | 0.89 | GRK2 (0.81) | GRK2ROCK1GRK5GRK1RPS6KB1 | |
| SCHEMBL2566311 | 0.89 | GRK2 (0.80) | GRK2ROCK1GRK5GRK1RPS6KB1 | |
| SCHEMBL17525399 | 0.88 | GRK2 (1.00) | GRK2ROCK1GRK5GRK1 | |
| SCHEMBL17525401 | 0.87 | GRK2 (0.78) | GRK2ROCK1GRK5GRK1RPS6KB1 | |
| Gsk-180736A SCHEMBL2569804 | 0.87 | GRK2 (1.00) | GRK2ROCK1GRK5GRK1RPS6KB1 | |
| Gsk-180736A SCHEMBL29431133 | 0.87 | GRK2 (1.00) | GRK2ROCK1GRK5GRK1RPS6KB1 | |
| SCHEMBL17525424 | 0.87 | GRK2 (1.00) | GRK2ROCK1GRK5GRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023564-B2 | G protein-coupled receptor kinase 2 inhibitors and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-07-17 | — | — | US | disclosed |
| US-10023564-B2 | G protein-coupled receptor kinase 2 inhibitors and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170240538-A1 | G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2017-08-24 | — | — | US | disclosed |
| US-20170240538-A1 | G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2017-08-24 | — | — | US | disclosed |
| WO-2016023028-A2 | G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-02-11 | — | — | WO | disclosed |
| WO-2016023028-A2 | G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023564-B2 | G protein-coupled receptor kinase 2 inhibitors and methods for use of the same | GRK2, GRK4, GRK5 | GRK2 1/4885ROCK1 349/4885GRK5 3/4885 |
| US-20170240538-A1 | G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME | GRK2, GRK4, GRK5 | GRK2 1/4885ROCK1 349/4885GRK5 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.