Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.83 |
| ▸ | PDE1A | P54750 | 3/20 | 0.83 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.83 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | HPGD | P15428 | 1/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.66 |
| ▸ | PDE6C | P51160 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.54 |
| ▸ | PDE6D | O43924 | 1/20 | 0.54 |
| ▸ | PDE8A | O60658 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31174349 | 0.91 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL1202 | 0.91 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL12462404 | 0.90 | PDE5A (0.84) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL1392 | 0.85 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL799 | 0.83 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL31202656 | 0.83 | PDE5A (0.86) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL3316795 | 0.83 | PDE5A (0.82) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL6718781 | 0.82 | PDE5A (0.85) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL6719476 | 0.81 | PDE5A (0.81) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL1160 | 0.80 | PDE5A (0.80) | PDE5APDE1APDE1BPDE1CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0463756-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| US-5346901-A | Treatment of angina, hypertension, heart failure and atherosclerosis | PFIZER INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5250534-A | Inhibitors of cyclic guanosine 3*,5*-monophosphate phosphodiesterase | PFIZER INC. (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0463756-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1992-01-02 | — | — | EP | disclosed |