Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 12/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17510090 | 1.00 | S1PR1 (0.37) | S1PR1S1PR5S1PR4DRD4SIGMAR1 | |
| SCHEMBL17510091 | 0.92 | S1PR1 (0.36) | S1PR1S1PR5S1PR4DRD4SIGMAR1 | |
| SCHEMBL2321515 | 0.91 | S1PR1 (0.41) | S1PR1S1PR5S1PR4PRKXIKBKE | |
| SCHEMBL17510081 | 0.91 | S1PR1 (0.41) | S1PR1S1PR5DRD4SIGMAR1TMEM97 | |
| SCHEMBL2324819 | 0.91 | S1PR1 (0.41) | S1PR1S1PR5S1PR4PRKXIKBKE | |
| SCHEMBL10088888 | 0.87 | S1PR1 (0.42) | S1PR1S1PR5S1PR4PRKXIKBKE | |
| SCHEMBL2325671 | 0.85 | MAPK1 (0.36) | S1PR1S1PR5S1PR4MAPK1 | |
| SCHEMBL10089075 | 0.84 | MAPK1 (0.36) | S1PR1S1PR5S1PR4MAPK1 | |
| SCHEMBL12441586 | 0.84 | MAPK1 (0.35) | S1PR1S1PR5S1PR4MAPK1 | |
| SCHEMBL2329535 | 0.83 | S1PR5 (0.44) | S1PR1S1PR5S1PR4PRKXIKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2354134-B1 | 2H-CHROMENE DERIVATIVES AS STIMULATORS OF SPHINGOSINE 1-PHOSPHATE RECEPTOR | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | claimed |