⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751779 | 0.78 | — | — | |
| SCHEMBL31322944 | 0.65 | — | — | |
| SCHEMBL1752214 | 0.65 | — | — | |
| SCHEMBL31322905 | 0.65 | — | — | |
| SCHEMBL11443061 | 0.64 | — | — | |
| SCHEMBL7373104 | 0.62 | — | — | |
| SCHEMBL3798872 | 0.61 | — | — | |
| SCHEMBL8652975 | 0.61 | — | — | |
| SCHEMBL16264292 | 0.61 | — | — | |
| SCHEMBL5709793 | 0.60 | HTT (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968584-B2 | Substituted arylpyrazoles | PFIZER INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7645786-B2 | 1-aryl-4-cyclopropylpyrazoles with at least one fluorine attached to the cyclopropyl ring; parasiticides; fleas; extended duration of action for at least 28 days | PFIZER INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20090186924-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER INC. (US) | 2009-07-23 | — | — | US | disclosed |
| US-7538134-B2 | Substituted arylpyrazoles | PFIZER INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-20080176865-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2008-07-24 | — | — | US | disclosed |
| US-20080146643-A1 | COMBINATION | PFIZER LIMITED (GB) | 2008-06-19 | — | — | US | disclosed |
| US-20070149464-A1 | COMBINATION | PFIZER INC. (US) | 2007-06-28 | — | — | US | disclosed |
| US-20070149550-A1 | 1-aryl-4-cyclopropylpyrazoles with at least one fluorine attached to the cyclopropyl ring; parasiticides; fleas; extended duration of action for at least 28 days | PFIZER INC. (US) | 2007-06-28 | — | — | US | disclosed |
| WO-2006134459-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2006-12-21 | — | — | WO | disclosed |
| US-20060287365-A1 | Substituted arylpyrazoles | ZOETIS LLC | 2006-12-21 | — | — | US | disclosed |