Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.75 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.62 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19161146 | 1.00 | HDAC6 (0.75) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19139005 | 1.00 | HDAC6 (0.75) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19168055 | 0.92 | HDAC6 (0.64) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19161681 | 0.90 | HDAC6 (0.77) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL17520635 | 0.90 | HDAC6 (0.76) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19138992 | 0.89 | HDAC6 (0.75) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19161934 | 0.89 | HDAC6 (0.75) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19161255 | 0.89 | HDAC6 (0.78) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19138956 | 0.88 | HDAC6 (0.82) | HDAC6HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19161261 | 0.88 | HDAC6 (0.82) | HDAC6HDAC1HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016020369-A1 | NOVEL HDAC6 INHIBITORS AND THEIR USES | UNIVERSITÄT REGENSBURG (DE) | 2016-02-11 | — | — | WO | disclosed |