Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14998057 | 0.89 | PDE5A (0.48) | PDE5AALDH1A1PKM | |
| SCHEMBL18672348 | 0.87 | PDE5A (0.46) | PDE5A | |
| SCHEMBL255981 | 0.85 | PDE5A (0.49) | PDE5A | |
| SCHEMBL2883538 | 0.85 | PDE5A (0.53) | PDE5AELANEMEN1KMT2AALDH1A1 | |
| SCHEMBL18672347 | 0.85 | PDE5A (0.51) | PDE5AMEN1KMT2A | |
| SCHEMBL31630833 | 0.85 | PDE5A (0.51) | PDE5AMEN1KMT2A | |
| SCHEMBL174635 | 0.84 | PDE5A (0.48) | PDE5A | |
| Hydrochloric Acid SCHEMBL29219152 | 0.83 | PDE5A (0.47) | PDE5A | |
| Acetic Acid SCHEMBL428284 | 0.80 | PDE5A (0.48) | PDE5A | |
| SCHEMBL29859246 | 0.80 | GUCY1A1 (0.52) | PDE5AALDH1A1BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219952-A1 | PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3 -YL]PYRIMIDIN-5-YL} CARBAMATE | ADVERIO PHARMA GMBH (DE) | 2023-07-13 | — | — | US | disclosed |
| US-20230219952-A1 | PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3 -YL]PYRIMIDIN-5-YL} CARBAMATE | ADVERIO PHARMA GMBH (DE) | 2023-07-13 | — | — | US | disclosed |
| WO-2021254981-A1 | PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL]PYRIMIDIN-5-YL}CARBAMATE | ADVERIO PHARMA GMBH (DE) | 2021-12-23 | — | — | WO | disclosed |
| EP-3925953-A1 | PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL]PYRIMIDIN-5-YL}CARBAMATE | Adverio Pharma GmbH (DE) | 2021-12-22 | — | — | EP | disclosed |
| EP-3421470-B1 | SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES IN CRYSTALLINE FORM | ADVERIO PHARMA GMBH (DE) | 2021-01-20 | — | — | EP | disclosed |
| EP-3421470-B1 | SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES IN CRYSTALLINE FORM | ADVERIO PHARMA GMBH (DE) | 2021-01-20 | — | — | EP | disclosed |
| US-10633356-B2 | Hydrates of substituted 5-fluoro-1H-pyrazolopyridines | ADVERIO PHARMA GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-10633356-B2 | Hydrates of substituted 5-fluoro-1H-pyrazolopyridines | ADVERIO PHARMA GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-10633357-B2 | Intermediates and process for preparing intermediates in the production of substituted pyrazolopyridines | ADVERIO PHARMA GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-10633357-B2 | Intermediates and process for preparing intermediates in the production of substituted pyrazolopyridines | ADVERIO PHARMA GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
| US-20130143900-A1 | Process for preparing substituted 5-fluoro-1H-pyrazolopyridines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-06-06 | — | — | US | disclosed |
| WO-2013076168-A1 | METHOD FOR PRODUCING SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2013-05-30 | — | — | WO | disclosed |
| WO-2013030288-A1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-07 | — | — | WO | disclosed |
| WO-2013030288-A1 | SUBSTITUTED ANNELLATED PYRIMIDINE AND THE USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-03-07 | — | — | WO | disclosed |
| WO-2012004258-A9 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012028647-A1 | BICYCLIC AZA HETEROCYCLES, AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028647-A1 | BICYCLIC AZA HETEROCYCLES, AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028645-A1 | METHOD FOR THE PRODUCTION OF 5-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028645-A1 | METHOD FOR THE PRODUCTION OF 5-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012004258-A1 | RING-FUSED PYRIMIDINES AND TRIAZINES AND USE THEREOF FOR THE TREATMENT AND/OR PROPHYLAXIS OF CARDIOVASCULAR DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633356-B2 | Hydrates of substituted 5-fluoro-1H-pyrazolopyridines | CYP3A5, KCNK5, CYP2F1 | PDE5A 72/4885ELANE 3905/4885MEN1 2007/4885 |
| US-20230219952-A1 | PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3 -YL]PYRIMIDIN-5-YL} CARBAMATE | POLL, DNMT3B, MTAP | PDE5A 429/4885ELANE 4858/4885MEN1 2231/4885 |
| US-10633357-B2 | Intermediates and process for preparing intermediates in the production of substituted pyrazolopyridines | CYP3A5, CYP4F2, CYP2F1 | PDE5A 109/4885ELANE 4703/4885MEN1 2576/4885 |
| US-20130143900-A1 | Process for preparing substituted 5-fluoro-1H-pyrazolopyridines | CYP3A5, CYP4F2, CYP2F1 | PDE5A 67/4885ELANE 4539/4885MEN1 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.