Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.60 |
| ▸ | PDE4A | P27815 | 10/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | VEGFA | P15692 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16056010 | 0.90 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7406620 | 0.85 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL16056262 | 0.81 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL28293800 | 0.81 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL3173894 | 0.76 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL21531660 | 0.75 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7295147 | 0.74 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| Rolipram SCHEMBL3719855 | 0.74 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7294928 | 0.74 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| (-)-Rolipram SCHEMBL576805 | 0.74 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160039827-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2016-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039827-A1 | ACTIVATION OF CARBONYL BETA-CARBONS FOR CHEMICAL TRANSFORMATIONS | CBR1, CBR3, CAT | PDE4B 1513/4885PDE4A 1813/4885PDE4C 1657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.