Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.63 |
| ▸ | BTK | Q06187 | 7/20 | 0.53 |
| ▸ | ITK | Q08881 | 7/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL414814 | 0.93 | KIT (0.63) | KITBTKITKAAK1NTRK1 | |
| SCHEMBL17319203 | 0.86 | KIT (0.61) | KITBTKITKAAK1NTRK1 | |
| SCHEMBL412758 | 0.85 | KIT (0.63) | KITBTKITKAAK1NTRK1 | |
| SCHEMBL857051 | 0.84 | KIT (0.57) | KITBTKITKAAK1NTRK1 | |
| SCHEMBL857930 | 0.82 | NTRK1 (0.60) | KITBTKITKNTRK1IGF1R | |
| SCHEMBL414770 | 0.81 | CYP2D6 (0.59) | AAK1CYP2D6NEK2CYP3A4CYP2C19 | |
| SCHEMBL857556 | 0.81 | NTRK1 (0.57) | KITBTKITKNTRK1DYRK1A | |
| SCHEMBL415590 | 0.80 | KIT (0.61) | KITBTKITKAAK1NTRK1 | |
| SCHEMBL414812 | 0.80 | AAK1 (0.63) | KITAAK1CYP2D6NEK2CYP3A4 | |
| SCHEMBL411253 | 0.78 | NTRK1 (0.58) | KITBTKITKNTRK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160046627-A1 | ITK and JAK Kinase Inhibitors | ARRIEN PHARMACEUTICALS LLC | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046627-A1 | ITK and JAK Kinase Inhibitors | JAK3, ITK, JAK2 | KIT 1308/4885BTK 58/4885ITK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.