Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17524354 | 0.81 | EGFR (0.61) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL3112115 | 0.78 | EGFR (1.00) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL2127801 | 0.78 | KDR (0.46) | EGFRMEN1KMT2AHTTKCNA5 | |
| SCHEMBL2126512 | 0.75 | MAP4K4 (0.51) | EGFRKMT2AHTTKDM4EHPGD | |
| SCHEMBL3112153 | 0.74 | EGFR (0.54) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL24329543 | 0.74 | EGFR (0.55) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL31178648 | 0.74 | EGFR (0.55) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL30530531 | 0.74 | EGFR (0.55) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL6181626 | 0.73 | MEN1 (1.00) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL2126015 | 0.73 | KDR (0.60) | CDK8TP53ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016021742-A1 | HETEROCYCLIC COMPOUNDS AS EP4 RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-02-11 | — | — | WO | disclosed |