Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.36 |
| ▸ | PDE2A | O00408 | 5/20 | 0.36 |
| ▸ | PDE6D | O43924 | 2/20 | 0.36 |
| ▸ | PDE6A | P16499 | 2/20 | 0.36 |
| ▸ | PDE6G | P18545 | 2/20 | 0.36 |
| ▸ | PDE6B | P35913 | 2/20 | 0.36 |
| ▸ | PDE6C | P51160 | 2/20 | 0.36 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL354615 | 0.91 | POLB (0.46) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL117229 | 0.90 | POLB (0.42) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL120109 | 0.89 | POLB (0.48) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL115920 | 0.89 | POLB (0.44) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL120121 | 0.88 | POLB (0.41) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL117897 | 0.87 | POLB (0.42) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL117769 | 0.87 | POLB (0.42) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL10284540 | 0.87 | POLB (0.42) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL354193 | 0.87 | POLB (0.45) | POLBSMN1; SMN2PDE10APDE2APDE6D | |
| SCHEMBL355786 | 0.86 | POLB (0.42) | POLBSMN1; SMN2PDE10APDE2APDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424856-A1 | FUSED HETEROCYCLIC COMPOUND AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2012-03-07 | — | — | EP | disclosed |