Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.37 |
| ▸ | DLK1 | P80370 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 3/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17525312 | 0.77 | IGF1R (0.47) | MAP3K14IGF1RNEK1 | |
| SCHEMBL25248571 | 0.76 | PAK1 (0.40) | MAP3K14MAP3K12DLK1IGF1RMAP4K1 | |
| SCHEMBL31140969 | 0.73 | JAK2 (0.35) | — | |
| SCHEMBL23887607 | 0.72 | SYK (0.42) | PIK3C3GRM5 | |
| SCHEMBL31141023 | 0.72 | MAP3K14 (0.41) | MAP3K14MAP3K12MAP4K1PAK4PAK1 | |
| SCHEMBL1164508 | 0.70 | IGF1R (0.65) | IGF1RPAK4PAK1NEK1 | |
| SCHEMBL3371250 | 0.70 | PIK3C3 (0.34) | MAP3K12PIK3C3IGF1RPAK4PAK1 | |
| SCHEMBL30532015 | 0.70 | LRRK2 (0.40) | IGF1RMAP4K1GRM5 | |
| SCHEMBL28673056 | 0.70 | LRRK2 (0.40) | IGF1RMAP4K1GRM5 | |
| SCHEMBL4066643 | 0.68 | IGF1R (0.42) | PIK3C3IGF1RPAK4PAK1NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024206628-A1 | MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN | NALO THERAPEUTICS (US) | 2024-10-03 | — | — | WO | disclosed |
| WO-2016022839-A1 | MODULATORS OF IRE1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-11 | — | — | WO | disclosed |