Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.70 |
| ▸ | AKT1 | P31749 | 1/20 | 0.66 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.66 |
| ▸ | GSK3A | P49840 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | STK4 | Q13043 | 1/20 | 0.66 |
| ▸ | STK3 | Q13188 | 1/20 | 0.66 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.66 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.66 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 3/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | YES1 | P07947 | 1/20 | 0.64 |
| ▸ | HCK | P08631 | 1/20 | 0.64 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.64 |
| ▸ | CCNK | O75909 | 1/20 | 0.60 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.60 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17525328 | 0.92 | SRC (0.69) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525309 | 0.90 | NEK1 (0.67) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525325 | 0.89 | NEK1 (0.82) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525341 | 0.88 | IGF1R (0.64) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525343 | 0.88 | NEK1 (0.67) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525331 | 0.88 | NEK1 (0.67) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525342 | 0.87 | SRC (0.64) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525314 | 0.87 | SRC (0.64) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525339 | 0.87 | IGF1R (0.72) | IGF1RAKT1TGFBR1GSK3AGSK3B | |
| SCHEMBL17525310 | 0.87 | SRC (0.64) | IGF1RAKT1TGFBR1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016022839-A1 | MODULATORS OF IRE1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-11 | — | — | WO | disclosed |