Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 5/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
| ▸ | PRKCA | P17252 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14725882 | 0.84 | PRKCQ (0.50) | PRKCQPRKCDPRKCACCND1CDK6 | |
| SCHEMBL9882034 | 0.83 | PRKCQ (0.67) | PRKCQPRKCDPRKCACCND1CDK6 | |
| SCHEMBL16863940 | 0.81 | PRKCQ (0.49) | PRKCQPRKCDPRKCAPRKD1 | |
| SCHEMBL14718139 | 0.81 | PRKCQ (0.63) | PRKCQPRKCDPRKCAPRKD1PIM1 | |
| SCHEMBL14718138 | 0.81 | PRKCQ (0.63) | PRKCQPRKCDPRKCAPRKD1PIM1 | |
| SCHEMBL16864088 | 0.81 | PRKCQ (0.49) | PRKCQPRKCDPRKCAPRKD1 | |
| SCHEMBL16864087 | 0.81 | PRKCQ (0.49) | PRKCQPRKCDPRKCAPRKD1 | |
| SCHEMBL1843636 | 0.81 | PRKCQ (0.49) | PRKCQPRKCDPRKCAPRKD1 | |
| SCHEMBL14725879 | 0.80 | PRKCQ (0.58) | PRKCQPRKCDPRKCAPRKD1 | |
| SCHEMBL799931 | 0.80 | PRKCQ (0.65) | PRKCQPRKCDPRKCAPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318408-B1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMA (US) | 2016-02-17 | — | — | EP | disclosed |